HiSCORE – Highly Informative Drug Screening by Overcoming NMR Restrictions
Ecole Normale Supérieure Department of Chemistry
About the Project
Our recently funded ERC Synergy Grant seeks to advance hyperpolarisation, miniaturisation, parallelisation and spin dynamics, and combine these research themes for highly informative drug discovery by nuclear magnetic resonance. We believe that, eventually, magnetic resonance can provide an in- depth biophysical characterisation of drug candidates in a much shorter time than today, and become a very effective platform for rapid drug discovery.
This interdisciplinary project is run by four laboratories (Geoffrey Bodenhausen, Arno Kentgens, Jan Korvink, and Benno Meier) in three institutions (ENS Paris, Radboud University Nijmegen, and Karlsruhe Institute of Technology). Our partners Alvar Gossert (ETH Zürich) and Claudio Dalvit (Trento) complete our team with strong expertise in magnetic resonance (MR) based drug discovery.
Due to the word limits, please refer to the attachement here for full information.
To apply for the PhD position, please combine your CV, a motivation letter, and reference letters (if available) into asingle PDF, and upload it below.
Some relevant references are given here:
Ligand−Protein Affinity Studies Using Long-Lived States of Fluorine- 19 Nuclei
From single to multiple microcoil flow probe NMR and related capillary techniques: a review
Microcoil nuclear magnetic resonance spectroscopy
Adiabatic Solid Effect
Characterization of Chemical Exchange Using Relaxation Dispersion of Hyperpolarized Nuclear Spins
Parallelized Ligand Screening Using Dissolution Dynamic Nuclear Polarization
To apply for this job please visit www.findaphd.com.